NSE2 (NSMCE2) Rabbit Polyclonal Antibody

CAT#: TA331411

Rabbit polyclonal Anti-NSMCE2 Antibody

Product Images

WB Suggested Anti-NSMCE2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: MCF7 cell lysate

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-NSMCE2 antibody: synthetic peptide directed towards the middle region of human NSMCE2. Synthetic peptide located within the following region: KFLALQSKNSDADFQNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDE
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 28 kDa
• Gene Name: NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
• Database Link:
  NP_775956
  Entrez Gene 286053 Human
  UniProt ID Q96MF7
• Background: NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
• Synonyms: C8orf36; MMS21; NSE2; ZMIZ7
• Note: Horse: 100%; Human: 100%; Rabbit: 100%; Pig: 86%; Bovine: 86%; Guinea pig: 86%; Mouse: 79%