hnRNP K (HNRNPK) Rabbit Polyclonal Antibody

CAT#: TA332421

Rabbit anti-HNRNPK Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using HNRNPK antibody.

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  Immunofluorescence analysis of MCF7 cell using HNRNPK antibody. Blue: DAPI for nuclear staining.

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  Immunofluorescence analysis of A549 cell using HNRNPK antibody.

Specifications

Product Data

• Applications: ELISA, ICC/IF, IHC, WB
• Recommended Dilution: WB,1:500 - 1:2000
  IHC-P,1:50 - 1:200
  IF/ICC,1:50 - 1:200
  ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Formulation: Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 51kDa
• Gene Name: heterogeneous nuclear ribonucleoprotein K
• Database Link:
  NP_002131
  Entrez Gene 15387 MouseEntrez Gene 117282 RatEntrez Gene 3190 Human
  UniProt ID P61978
• Background: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized.
• Synonyms: CSBP; HNRPK; TUNP

Reference Data

• Protein Pathways: Spliceosome