PTBP1 Rabbit Polyclonal Antibody

CAT#: TA332440

Rabbit anti-PTBP1 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using PTBP1 antibody.

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  Immunohistochemistry of paraffin-embedded rat brain using PTBP1 antibody at dilution of 1:100 (400x lens).

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  Immunohistochemistry of paraffin-embedded mouse lung using PTBP1 antibody at dilution of 1:100 (400x lens).

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  Immunohistochemistry of paraffin-embedded rat kidney using PTBP1 antibody at dilution of 1:100 (400x lens).

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human PTBP1
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 531
• Gene Name: polypyrimidine tract binding protein 1
• Database Link:
  NP_114367
  Entrez Gene 19205 MouseEntrez Gene 29497 RatEntrez Gene 5725 Human
  UniProt ID P26599
• Background: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been describ
• Synonyms: HNRNP-I; HNRNPI; HNRPI; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4

Reference Data

• Protein Families: Druggable Genome