Optineurin (OPTN) Rabbit Polyclonal Antibody

CAT#: TA332444

Rabbit anti-OPTN Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using OPTN antibody.

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  Immunohistochemistry of paraffin-embedded human esophageal cancer using OPTN antibody at dilution of 1:100 (200x lens).

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  Immunohistochemistry of paraffin-embedded rat kidney using OPTN antibody at dilution of 1:100 (200x lens).

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human OPTN
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 577
• Gene Name: optineurin
• Database Link:
  NP_068815
  Entrez Gene 71648 MouseEntrez Gene 10133 Human
  UniProt ID Q96CV9
• Background: This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
• Synonyms: ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP

Reference Data

• Protein Families: Druggable Genome