Lamin B1 (LMNB1) Rabbit Polyclonal Antibody

CAT#: TA332459

Rabbit polyclonal anti-Lamin B1 antibody, Loading control

Product Images

Western blot analysis of extracts of various cell lines, using LMNB1 antibody.

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  Immunofluorescence analysis of U2OS cell using LMNB1 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ChIP, ICC/IF, IHC, IP, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200;IF 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human LMNB1
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 586
• Gene Name: lamin B1
• Database Link:
  NP_005564
  Entrez Gene 16906 MouseEntrez Gene 116685 RatEntrez Gene 4001 Human
  UniProt ID P20700
• Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).
• Synonyms: ADLD; LMN; LMN2; LMNB