Constitutive androstane receptor (NR1I3) Rabbit Polyclonal Antibody

CAT#: TA332479

Rabbit anti-NR1I3 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using NR1I3 antibody.

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  Immunofluorescence analysis of U2OS cell using NR1I3 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000;IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human NR1I3
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 352
• Gene Name: nuclear receptor subfamily 1 group I member 3
• Database Link:
  NP_005113
  Entrez Gene 12355 MouseEntrez Gene 65035 RatEntrez Gene 9970 Human
  UniProt ID Q14994
• Background: This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene
• Synonyms: CAR; CAR1; MB67

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors