Choline Acetyltransferase (CHAT) Rabbit Polyclonal Antibody

CAT#: TA332522

Rabbit anti-CHAT Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using CHAT antibody.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human CHAT
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: choline O-acetyltransferase
• Database Link:
  NP_065574
  Entrez Gene 12647 MouseEntrez Gene 290567 RatEntrez Gene 1103 Human
  UniProt ID P28329
• Background: This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.
• Synonyms: CHOACTASE; CMS1A; CMS1A2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Glycerophospholipid metabolism