TIM 3 (HAVCR2) Rabbit Polyclonal Antibody

CAT#: TA332535

Rabbit anti-HAVCR2 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cells, using HAVCR2 antibody.

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  Western blot analysis of extracts of various cells, using HAVCR2 antibody.

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  Immunohistochemistry of paraffin-embedded human lung cancer using HAVCR2 antibody at dilution of 1:100 (x40 lens).

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  Immunohistochemistry of paraffin-embedded human lung cancer using HAVCR2 antibody at dilution of 1:100 (x40 lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:1000;IHC 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human HAVCR2
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 33 kDa
• Gene Name: hepatitis A virus cellular receptor 2
• Database Link:
  NP_116171
  Entrez Gene 171285 MouseEntrez Gene 84868 Human
  UniProt ID Q8TDQ0
• Background: The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
• Synonyms: CD366; HAVcr-2; KIM-3; Tim-3; TIM3; TIMD-3; TIMD3

Reference Data

• Protein Families: Druggable Genome, Transmembrane