ADAMTS4 Rabbit Polyclonal Antibody

CAT#: TA332540

Rabbit anti-ADAMTS4 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using ADAMTS4 antibody.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human ADAMTS4
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 837
• Gene Name: ADAM metallopeptidase with thrombospondin type 1 motif 4
• Database Link:
  NP_005090
  Entrez Gene 66015 RatEntrez Gene 240913 MouseEntrez Gene 9507 Human
  UniProt ID O75173
• Background: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
• Synonyms: ADAMTS-2; ADAMTS-4; ADMP-1

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein, Transmembrane