ACK1 (TNK2) Rabbit Polyclonal Antibody

CAT#: TA332541

Rabbit anti-TNK2 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using TNK2 antibody.

• 

  Immunohistochemistry of paraffin-embedded human kidney cancer using TNK2 antibody at dilution of 1:200 (400x lens).

• 

  Immunohistochemistry of paraffin-embedded human rectal cancer using TNK2 antibody at dilution of 1:200 (200x lens).

• 

  Immunohistochemistry of paraffin-embedded rat spleen using TNK2 antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human TNK2
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tyrosine kinase non receptor 2
• Database Link:
  NP_005772
  Entrez Gene 51789 MouseEntrez Gene 303882 RatEntrez Gene 10188 Human
  UniProt ID Q07912
• Background: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
• Synonyms: ACK; ACK-1; ACK1; p21cdc42Hs

Reference Data

• Protein Families: Druggable Genome, Protein Kinase