MRE11 Rabbit Polyclonal Antibody

CAT#: TA332553

Rabbit anti-MRE11A Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using MRE11A antibody.

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  Immunohistochemical of paraffin-embedded human stomach cancer using MRE11A antibody at dilution of 1:200 (400x lens).

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  Immunohistochemical of paraffin-embedded rat brain using MRE11A antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human MRE11A
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 80 kDa
• Gene Name: MRE11 homolog A, double strand break repair nuclease
• Database Link:
  NP_005582
  Entrez Gene 17535 MouseEntrez Gene 4361 Human
  UniProt ID P49959
• Background: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
• Synonyms: ATLD; HNGS1; MRE11; MRE11B

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Homologous recombination, Non-homologous end-joining