DIABLO Rabbit Polyclonal Antibody

CAT#: TA332556

Rabbit anti-DIABLO Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using DIABLO antibody.

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  Immunohistochemistry of paraffin-embedded human esophagus using DIABLO antibody at dilution of 1:100 (400x lens).

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  Immunohistochemical of paraffin-embedded human esophageal cancer using DIABLO antibody at dilution of 1:100 (400x lens).

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human DIABLO
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 239
• Gene Name: diablo IAP-binding mitochondrial protein
• Database Link:
  NP_620308
  Entrez Gene 66593 MouseEntrez Gene 288753 RatEntrez Gene 56616 Human
  UniProt ID Q9NR28
• Background: This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Synonyms: DFNA64; SMAC

Reference Data

• Protein Families: Transmembrane