SDHA Rabbit Polyclonal Antibody

CAT#: TA332575

Rabbit anti-SDHA Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using SDHA antibody.

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  Immunohistochemistry of paraffin-embedded rat heart using SDHA antibody at dilution of 1:100 (400x lens).

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  Immunohistochemistry of paraffin-embedded rat heart using SDHA antibody at dilution of 1:100 (400x lens).

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  Immunohistochemistry of paraffin-embedded human liver cancer using SDHA antibody at dilution of 1:100 (400x lens).

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  Immunohistochemistry of paraffin-embedded human esophageal cancer using SDHA antibody at dilution of 1:100 (400x lens).

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200;IF 1:10 - 1:100
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human SDHA
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 72 kDa
• Gene Name: succinate dehydrogenase complex flavoprotein subunit A
• Database Link:
  NP_004159
  Entrez Gene 66945 MouseEntrez Gene 157074 RatEntrez Gene 6389 Human
  UniProt ID P31040
• Background: This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29.
• Synonyms: CMD1GG; FP; PGL5; SDH1; SDH2; SDHF

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease