CPT1A Rabbit Polyclonal Antibody

CAT#: TA332600

Rabbit anti-CPT1A Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using CPT1A antibody.

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  Immunohistochemical of paraffin-embedded human liver cancer using CPT1A antibody at dilution of 1:200 (400x lens).

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  Immunofluorescence analysis of MCF-7 cell using CPT1A antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000, IHC 1:50- 1:200, IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human CPT1A
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: carnitine palmitoyltransferase 1A
• Database Link:
  NP_001867
  Entrez Gene 12894 MouseEntrez Gene 25757 RatEntrez Gene 1374 Human
  UniProt ID P50416
• Background: The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Synonyms: CPT1; CPT1-L; L-CPT1

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Adipocytokine signaling pathway, Fatty acid metabolism, PPAR signaling pathway