Repulsive Guidance Molecule C (HFE2) Rabbit Polyclonal Antibody

CAT#: TA332627

Rabbit anti-HFE2 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using HFE2 antibody.

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: WB,1:500 - 1:2000
  ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
• Reactivities: Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Formulation: Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 45kDa
• Gene Name: hemochromatosis type 2 (juvenile)
• Database Link:
  NP_973733
  Entrez Gene 69585 MouseEntrez Gene 310681 Rat
  UniProt ID Q6ZVN8
• Background: The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
• Synonyms: HFE2A; HJV; JH; RGMC

Reference Data

• Protein Families: Transmembrane