IMPDH2 Rabbit Polyclonal Antibody

CAT#: TA332628

Rabbit anti-IMPDH2 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using IMPDH2 antibody.

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  Immunofluorescence analysis of HeLa cell using IMPDH2 antibody.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000;IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human IMPDH2
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 514
• Gene Name: IMP (inosine 5'-monophosphate) dehydrogenase 2
• Database Link:
  NP_000875
  Entrez Gene 23918 MouseEntrez Gene 301005 RatEntrez Gene 3615 Human
  UniProt ID P12268
• Background: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
• Synonyms: IMPD2; IMPDH-II

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism