PSMD7 Rabbit Polyclonal Antibody

CAT#: TA332634

Rabbit anti-PSMD7 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using PSMD7 antibody.

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  Immunohistochemistry of paraffin-embedded human breast cancer using PSMD7 antibody at dilution of 1:200 (400x lens).

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  Immunohistochemistry of paraffin-embedded human thyroid cancer using PSMD7 antibody at dilution of 1:200 (400x lens).

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  Immunofluorescence analysis of U2OS cell using PSMD7 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200;IF 1:50- 1:200
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human PSMD7
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 324
• Gene Name: proteasome 26S subunit, non-ATPase 7
• Database Link:
  NP_002802
  Entrez Gene 17463 MouseEntrez Gene 5713 Human
  UniProt ID P51665
• Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17.
• Synonyms: MOV34; P40; Rpn8; S12

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Proteasome