Diazepam Binding Inhibitor (DBI) Rabbit Polyclonal Antibody

CAT#: TA332648

Rabbit anti-DBI Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using DBI antibody.

Specifications

Product Data

• Applications: IP, WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human DBI
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: diazepam binding inhibitor, acyl-CoA binding protein
• Database Link:
  NP_065438
  Entrez Gene 1622 Human
  UniProt ID P07108
• Background: This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.
• Synonyms: ACBD1; ACBP; CCK-RP; EP

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: PPAR signaling pathway