Plakophilin 2 (PKP2) Rabbit Polyclonal Antibody

CAT#: TA332735

Rabbit anti-PKP2 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using PKP2 antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human PKP2
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: plakophilin 2
• Database Link:
  NP_001005242
  Entrez Gene 67451 MouseEntrez Gene 287925 RatEntrez Gene 5318 Human
  UniProt ID Q99959
• Background: This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.
• Synonyms: ARVD9

Reference Data

• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC)