TPP1 Rabbit Polyclonal Antibody

CAT#: TA332799

Rabbit anti-TPP1 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using TPP1 antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human TPP1
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 563
• Gene Name: tripeptidyl peptidase 1
• Database Link:
  NP_000382
  Entrez Gene 12751 MouseEntrez Gene 1200 Human
  UniProt ID O14773
• Background: This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.
• Synonyms: CLN2; GIG1; LPIC; SCAR7; TPP-1

Reference Data

• Protein Families: Protease
• Protein Pathways: Lysosome