FMRP (FMR1) Rabbit Polyclonal Antibody

CAT#: TA332811

Rabbit anti-FMR1 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using FMR1 antibody.

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  Immunohistochemistry of paraffin-embedded human kidney cancer using FMR1 antibody at dilution of 1:200 (400x lens).

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  Immunohistochemistry of paraffin-embedded human thyroid cancer using FMR1 antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human FMR1
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: fragile X mental retardation 1
• Database Link:
  NP_002015
  Entrez Gene 14265 MouseEntrez Gene 24948 RatEntrez Gene 2332 Human
  UniProt ID Q06787
• Background: The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
• Synonyms: FMRP; FRAXA; POF; POF1; POFX

Reference Data

• Protein Families: Druggable Genome