Thymine DNA glycosylase (TDG) Rabbit Polyclonal Antibody

CAT#: TA332890

Rabbit anti-TDG Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using TDG antibody.

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: WB,1:500 - 1:1000
  ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Formulation: Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 46kDa
• Gene Name: thymine DNA glycosylase
• Database Link:
  NP_003202
  Entrez Gene 21665 MouseEntrez Gene 114521 RatEntrez Gene 6996 Human
  UniProt ID Q13569
• Background: The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
• Synonyms: hTDG

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Base excision repair