VASP Rabbit Polyclonal Antibody

CAT#: TA333056

Phospho-VASP-S239 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts from serum-treated 293 and PMA-treated C6 cells, using phospho-VASP-S239 antibody.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:1000;IHC 1:50- 1:100
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A phospho specific peptide corresponding to residues surrounding S239 of human VASP
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 380
• Gene Name: vasodilator-stimulated phosphoprotein
• Database Link:
  NP_003361
  Entrez Gene 22323 MouseEntrez Gene 361517 RatEntrez Gene 7408 Human
  UniProt ID P50552
• Background: Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.
• Synonyms: vasodilator-stimulated phosphoprotein

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Fc gamma R-mediated phagocytosis, Focal adhesion, Leukocyte transendothelial migration