CDK1 Rabbit Polyclonal Antibody

CAT#: TA333178

Phospho-CDK1-T161 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts from Hela cells using Phospho-CDK1-T161 antibody.

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  Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using Phospho-CDK1-T161 antibody.

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: WB 1:500-1:2000;IHC 1:50-1:100
• Reactivities: Human, Mouse
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A phospho specific peptide corresponding to residues surrounding T161 of human CDK1
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 297
• Gene Name: cyclin-dependent kinase 1
• Database Link:
  NP_001777
  Entrez Gene 12534 MouseEntrez Gene 983 Human
  UniProt ID P06493
• Background: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Synonyms: CDC2; CDC28A; P34CDC2

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Stem cell - Pluripotency
• Protein Pathways: Cell cycle, Gap junction, Oocyte meiosis, p53 signaling pathway, Progesterone-mediated oocyte maturation