CDK2 Rabbit Polyclonal Antibody

CAT#: TA333179

Phospho-CDK2-T160 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts from Hela cells using Phospho-CDK2-T160 antibody.

• 

  Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using Phospho-CDK2-T160 antibody.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500-1:2000;IHC 1:50-1:100
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A phospho specific peptide corresponding to residues surrounding T160 of human CDK2
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 298
• Gene Name: cyclin-dependent kinase 2
• Database Link:
  NP_439892
  Entrez Gene 12566 MouseEntrez Gene 362817 RatEntrez Gene 1017 Human
  UniProt ID P24941
• Background: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
• Synonyms: CDKN2; p33(CDK2)

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Cell cycle, Oocyte meiosis, p53 signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Small cell lung cancer