IFNAR1 Rabbit Polyclonal Antibody

CAT#: TA333216

Phospho-IFNAR1-S535/S539 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts from 293 cells, using phospho-IFNAR1-S535/S539 antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A phospho specific peptide corresponding to residues surrounding S535/S539 of human IFNAR1
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 557
• Gene Name: interferon alpha and beta receptor subunit 1
• Database Link:
  NP_000620
  Entrez Gene 3454 Human
  UniProt ID P17181
• Background: The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.
• Synonyms: AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Toll-like receptor signaling pathway