JAK2 Rabbit Polyclonal Antibody

CAT#: TA333223

Phospho-JAK2-Y221 Rabbit Polyclonal Antibody

Product Images

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using phospho-JAK2-Y221 antibody.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC 1:50-1:100
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A phospho specific peptide corresponding to residues surrounding Y221 of human JAK2
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 1132
• Gene Name: Janus kinase 2
• Database Link:
  NP_004963
  Entrez Gene 16452 MouseEntrez Gene 24514 RatEntrez Gene 3717 Human
  UniProt ID O60674
• Background: This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
• Synonyms: JTK10; THCYT3

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Adipocytokine signaling pathway, Chemokine signaling pathway, Jak-STAT signaling pathway