AMPK alpha 1 (PRKAA1) Rabbit Polyclonal Antibody

CAT#: TA333273

Phospho-PRKAA1-T174/T172 Rabbit Polyclonal Antibody

Product Images

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using Phospho-PRKAA1-T174/T172 antibody.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC 1:50-1:100
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A phospho specific peptide corresponding to residues surrounding T174/T172 of human PRKAA1
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 559
• Gene Name: protein kinase AMP-activated catalytic subunit alpha 1
• Database Link:
  NP_996790
  Entrez Gene 65248 RatEntrez Gene 105787 MouseEntrez Gene 5562 Human
  UniProt ID Q13131
• Background: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
• Synonyms: AMPK; AMPKa1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Adipocytokine signaling pathway, Hypertrophic cardiomyopathy (HCM), Insulin signaling pathway, mTOR signaling pathway, Regulation of autophagy