SRC Rabbit Polyclonal Antibody

CAT#: TA333292

Phospho-SRC-Y418 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts from COLO205 cells, using Phospho-SRC-Y418 antibody.

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  Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue, using Phospho-SRC-Y418 antibody.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500-1:2000;IHC 1:50-1:100
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A phospho specific peptide corresponding to residues surrounding Y418 of human SRC
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 536
• Gene Name: SRC proto-oncogene, non-receptor tyrosine kinase
• Database Link:
  NP_938033
  Entrez Gene 20779 MouseEntrez Gene 83805 RatEntrez Gene 6714 Human
  UniProt ID P12931
• Background: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
• Synonyms: ASV; c-SRC; p60-Src; SRC1; THC6

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Stem cell relevant signaling - JAK/STAT signaling pathway
• Protein Pathways: Adherens junction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, GnRH signaling pathway, Tight junction, VEGF signaling pathway