ZAP70 Rabbit Polyclonal Antibody

CAT#: TA333306

Phospho-ZAP70-Y493 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts from JK cells, using Phospho-ZAP70-Y493 antibody.

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  Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using Phospho-ZAP70-Y493 antibody.

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500-1:2000;IHC 1:50-1:100
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A phospho specific peptide corresponding to residues surrounding Y493 of human ZAP70
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 619
• Gene Name: zeta chain of T cell receptor associated protein kinase 70kDa
• Database Link:
  NP_001070
  Entrez Gene 22637 MouseEntrez Gene 301348 RatEntrez Gene 7535 Human
  UniProt ID P43403
• Background: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
• Synonyms: SRK; STCD; STD; TZK; ZAP-70

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Natural killer cell mediated cytotoxicity, Primary immunodeficiency, T cell receptor signaling pathway