RAD17 Rabbit Polyclonal Antibody

CAT#: TA336267

Rabbit Polyclonal Rad17 Antibody

Product Images

Western Blot: Rad17 Antibody TA336267 - WB detection of RAD17 protein in human heart lysate using TA336267 at a dilution of 1:500

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500 -1:1000
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide made to a N-terminal region of human RAD17.
• Formulation: PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 66 kDa
• Gene Name: RAD17 checkpoint clamp loader component
• Database Link:
  NP_579922
  Entrez Gene 5884 Human
  UniProt ID O75943
• Background: Signals originating from damaged DNA activate checkpoint pathways and target the mitotic apparatus via a number a distinct mechanisms. These checkpoints link damage to DNA with the components of the cell cycle through signal transduction systems. In mammals, five genes have been identified as components of DNA damage-induced checkpoint pathways: ATM, p53, p21/WAF1/CIP1, hCHK1, and 14-3-3sigma. When overexpressed in mammalian cells, hRAD17 activates p53 and causes an accumulation of G1 phase cells, suggesting an involvement of the hRAD17 gene in this checkpoint pathway.(1).
• Synonyms: CCYC; HRAD17; R24L; RAD17SP; RAD24
• Note: This antibody is useful for Western Blot. Flow Cytometry was reported in scientific literature.

Reference Data

• Protein Families: Druggable Genome