FANCD2 Rabbit Polyclonal Antibody
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Other products for "FANCD2"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | Immunocytochemistry/ Immunofluorescence: 5 ug/ml, Chromatin Immunoprecipitation (ChIP), Flow Cytometry: 2 - 5 ug/ml, Simple Western: 1:25, Immunoprecipitation: 1:10-1:500, Immunohistochemistry-Paraffin: 2.5-5.0 ug/ml, Immunohistochemistry: 2.5-5.0 ug/ml, Western Blot: 1 - 2 ug/ml, RNA Inhibition, Immunoblotting, Chromatin Immunoprecipitation, Knockdown Validated, Knockout Validated |
Reactivities | Human, Mouse, Primate |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Human FANCD2 fusion protein (N-terminal fragment). [Swiss-Prot #Q9BXW9] |
Formulation | Tris-glycine, 150mM NaCl, pH7.5, 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
Concentration | lot specific |
Purification | Affinity purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | Fanconi anemia complementation group D2 |
Database Link | |
Background | Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation (IR). DNA damage activates the monoubiquitination of FANCD2, targeting nuclear foci containing the BRCA1 protein. |
Synonyms | FA-D2; FA4; FACD; FAD; FAD2; FANCD |
Note | By Western blot, this antibody should recognize a band at ~166 kDa (post-translationally modified form). Additional bands may be seen at lower molecular weights. For immunofluorescence it has been tested in human MMC and IR treated MEF cells. This antibody may also be used for Immunoprecipitation and Immunohistochemistry-Paraffin |
Reference Data | |
Protein Families | Druggable Genome |
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