EAAT1 (SLC1A3) Rabbit Polyclonal Antibody

CAT#: TA336274

Rabbit Polyclonal EAAT1/GLAST-1/SLC1A3 Antibody


USD 457.00

5 Days*

Size
    • 100 ul

Frequently bought together (2)
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Specifications

Product Data
Applications IHC, WB
Recommended Dilution Flow (Intracellular): 1:500, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunohistochemistry: 1:10-1:500, Immunohistochemistry-Frozen: 1:10-1:500, ELISA: 1:100 - 1:2000, Flow Cytometry: 1:200-1:500, Immunohistochemistry-Paraffin: 1:50-1:500, Western Blot: 2 ug/ml
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide made to a C-terminal portion of the rat SLC1A3 protein (between residues 500-542) [UniProt P24942]
Formulation PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 60 kDa
Gene Name solute carrier family 1 member 3
Background Excitatory amino acid transporter 1 (SLC1A3), also known as sodium-dependent glutamate/aspartate transporter 1, GLAST-1, solute carrier family 1 member 3, EAAT1, and EA6, transports and regulates L-glutamate, D-aspartate, and L-aspartate. SLC1A3 ends the glutamate postsynaptic actions by removing remaining glutamate from the cleft and by reducing extracellular glutamate. SLC1A3 is a member of a family of high affinity sodium-dependent transporter molecules that regulate neurotransmitter concentrations at the excitatory glutamatergic synapses of the mammalian central nervous system. In addition, SLC1A3 may also be important for the prevention of glutamate excitotoxicity. The SLC1A3 protein is located on the cell membrane. SLC1A3 is prominently expressed in the cerebellum, frontal cortex, hippocampus and basal ganglia and is also reported to be found in heart, placenta, lung and striated muscle. The SLC1A3 protein is subject to glycosylation and phosphorylation. SLC1A3 has two known isoforms (59.5 and 55 kDa) formed by alternative splicing. Mutations in the SLC1A3 gene have been linked to episodic ataxia and hemiplegia (PMID: 16116111) while other mutations result in a form of SLC1A3 (E219D) which influences Tourette syndrome (PMID: 21233784).
Synonyms EA6; EAAT1; GLAST; GLAST1
Reference Data
Protein Families Transmembrane

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