RUNX1 Rabbit Polyclonal Antibody

CAT#: TA336280

Rabbit Polyclonal RUNX1/CBFA2 Antibody

Product Images

Western Blot: RUNX1/CBFA2 Antibody TA336280 - Used at 5 ug/ml to analyze AML1 in (A) human Ramosand (B) mouse Raw cell lysate.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 2-5 ug/ml
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Rabbit anti-AML-1 polyclonal antibody was raised against a peptide corresponding to a sequence that is homologous in AML-1 and AML-1/ETO (amino acids 231 to 245 of human origin).
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 49 kDa
• Gene Name: runt related transcription factor 1
• Database Link:
  NP_001745
  Entrez Gene 12394 MouseEntrez Gene 861 Human
  UniProt ID Q01196
• Background: AML-1 is a DNA-binding protein which specifically interacts with a sequence belonging to the group of enhancer core motifs, TGT/cGGT. The AML1 gene on chromosome 21 is disrupted in the (8;21)(q22;q22) translocation associated with acute myelogenous leukemia and encodes a protein with a central 118-amino-acid domain with 69% homology to the Drosophila pair-rule gene, runt. AML-1 translocation is frequently observed in acute myeloid leukemia. It is a key transactivator of tissue-specific genes of the hematopoietic and bone lineages.
• Synonyms: AML1; AML1-EVI-1; AMLCR1; CBFA2; EVI-1; PEBP2aB

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Chronic myeloid leukemia, Pathways in cancer