IRE1 (ERN1) Rabbit Polyclonal Antibody

CAT#: TA336286

Rabbit Polyclonal IRE1 alpha [p Ser724] Antibody


USD 512.00

2 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Applications WB
Recommended Dilution Western Blot: 1:500 - 1:1000, Knockdown Validated, Immunocytochemistry/ Immunofluorescence: 1:10 - 1:500, Chromatin Immunoprecipitation (ChIP), Immunoblotting, In vitro assay, Immunohistochemistry-Paraffin: 1:10 - 1:500, Immunohistochemistry-Frozen: 1:10 - 1:500, ELISA: 1:100 - 1:2000, Immunohistochemistry: 1:10 - 1:500, Immunoprecipitation: 1:10 - 1:500
Reactivities Human, Mouse, Rat, Rabbit (Does not react with: Primate)
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide surrounding the phosphorylated serine 724 of the human IRE1 alpha protein. [Swiss-Prot #O75460]
Formulation PBS, 0.01% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name endoplasmic reticulum to nucleus signaling 1
Background IRE1 acts as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA converting it into a potent unfolded-protein response transcriptional activator. It is a transmembrane protein that has both serine-threonine kinase and endoribonuclease activities. mutants are viable, but IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER.
Synonyms hIRE1p; IRE1; IRE1a; IRE1P
Note This IRE1 pS724 antibody is useful for Western blot, ELISA, and Immunohistochemistry paraffin embedded sections.(PMID: 19264902) Use in Immunohistochemistry-Frozen reported in scientific literature (PMID 24823368)
Reference Data
Protein Families Protein Kinase, Transmembrane
Protein Pathways Alzheimer's disease

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.