HDAC6 Rabbit Polyclonal Antibody

CAT#: TA336337

Rabbit Polyclonal HDAC6 Antibody


USD 424.00

5 Days*

Size
    • 100 ug

Product Images

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Specifications

Product Data
Applications WB
Recommended Dilution Chromatin Immunoprecipitation (ChIP): 1:20-1:1000, Immunoprecipitation: assay dependent, Western Blot: 2 - 5 ug/ml, Simple Western: 1:20, Immunocytochemistry/ Immunofluorescence: 2 - 5 ug/ml, Chromatin Immunoprecipitation: 1:20-1:1000
Reactivities Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen This antibody was generated by immunizing rabbits with a synthetic peptide corresponding to amino acids 1-16 of human HDAC6.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name histone deacetylase 6
Background Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.
Synonyms CPBHM; HD6; JM21; PPP1R90
Note Chromatin Immunoprecipitation: Refer to Imbriano (2005) for details.
Reference Data
Protein Families Druggable Genome, Transcription Factors

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