SIRT7 Rabbit Polyclonal Antibody

CAT#: TA336342

Rabbit Polyclonal SIRT7 Antibody

Product Images

Western Blot: SIRT7 Antibody TA336342 - Analysis of SIRT7 in A) human liver and B) PBMC lysate using this antibody at 1 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1-3 ug/ml
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A mixture of synthetic peptides corresponding to amino acids 35-51 and 361-377 of human SIRT7 was used as immunogen.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: sirtuin 7
• Database Link:
  NP_057622
  Entrez Gene 51547 Human
  UniProt ID Q9NRC8
• Background: SIRT7 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.
• Synonyms: SIR2L7

Reference Data

• Protein Families: Druggable Genome, Transcription Factors