RANKL (TNFSF11) Rabbit Polyclonal Antibody

CAT#: TA336347

Rabbit Polyclonal TRANCE/TNFSF11/RANK L Antibody

Product Images

Western Blot: TRANCE/TNFSF11/RANK L Antibody TA336347 - Analysis of CD254. A. CD254 recombinant protein fragment. Note: this is not a full-length protein. B. LNCaP lysate using CD254 antibody at 0.5 ug/mL.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 0.5 ug/mL, Immunohistochemistry
• Reactivities: Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to amino acids 161-177 of mouse CD254 (AQPFAHLTINAASIPSG) was used as immunogen for this antibody.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tumor necrosis factor superfamily member 11
• Database Link:
  NP_003692
  Entrez Gene 21943 MouseEntrez Gene 117516 Rat
  UniProt ID O14788
• Background: TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells (1-2). RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). TRANCE/RANKL is also important in T- and B-cell maturation (3). As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis (4,5). OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis (3). Mouse Trance/RANKL is a 316 amino acid protein.
• Synonyms: CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TRANCE

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction