TIM 3 (HAVCR2) Rabbit Polyclonal Antibody
Frequently bought together (2)
Transient overexpression lysate of hepatitis A virus cellular receptor 2 (HAVCR2)
USD 396.00
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Specifications
Product Data | |
Applications | WB |
Recommended Dilution | Western Blot: 1-3 ug/ml |
Reactivities | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A portion of amino acids 100-200 of mouse TIM-3 protein were used as the immunogen. |
Formulation | PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Concentration | lot specific |
Purification | Protein G purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | hepatitis A virus cellular receptor 2 |
Database Link | |
Background | Official Gene Symbol HAVCR2 Gene ID 84868(Human) Gene Map Locus 5q33.3(Human) HAVCR2 is a 281 A.A Type-1 Th1 specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. It consists of an IgV-region like domain and a mucin-like domain in the extracellular region and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. HAVCR2 regulates macrophage activation thereby down regulating aggressive Th-1 mediated immune responses and facilitates in the development of immune tolerance. It plays an important role in the induction of autoimmune diseases by regulating macrophage activation. Pathological significance of HAVCR2 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease. |
Synonyms | CD366; HAVcr-2; KIM-3; Tim-3; TIM3; TIMD-3; TIMD3 |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Documents
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