TIM 3 (HAVCR2) Rabbit Polyclonal Antibody

CAT#: TA336355

Rabbit Polyclonal TIM-3 Antibody

Product Images

Western Blot: TIM-3 Antibody TA336355 - Analysis of TIM-3 in (A) mouse and (B) rat kidney cell lysate using this antibody at 2 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1-3 ug/ml
• Reactivities: Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A portion of amino acids 100-200 of mouse TIM-3 protein were used as the immunogen.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: hepatitis A virus cellular receptor 2
• Database Link:
  NP_116171
  Entrez Gene 171285 Mouse
  UniProt ID Q8TDQ0
• Background: Official Gene Symbol HAVCR2 Gene ID 84868(Human) Gene Map Locus 5q33.3(Human) HAVCR2 is a 281 A.A Type-1 Th1 specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. It consists of an IgV-region like domain and a mucin-like domain in the extracellular region and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. HAVCR2 regulates macrophage activation thereby down regulating aggressive Th-1 mediated immune responses and facilitates in the development of immune tolerance. It plays an important role in the induction of autoimmune diseases by regulating macrophage activation. Pathological significance of HAVCR2 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease.
• Synonyms: CD366; HAVcr-2; KIM-3; Tim-3; TIM3; TIMD-3; TIMD3

Reference Data

• Protein Families: Druggable Genome, Transmembrane