Corticotropin Releasing Factor Receptor 2 (CRHR2) Rabbit Polyclonal Antibody
Frequently bought together (2)
Transient overexpression lysate of corticotropin releasing hormone receptor 2 (CRHR2)
USD 396.00
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Specifications
Product Data | |
Applications | WB |
Recommended Dilution | Immunocytochemistry/ Immunofluorescence, Simple Western: 1:200, Western Blot: 0.5-2 ug/ml |
Reactivities | Human, Mouse, Rat, Bovine, Canine, Chicken |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A portion of amino acids 75-125 of human CRHR2 was used as the immunogen. |
Formulation | PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Concentration | lot specific |
Purification | Protein G purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | corticotropin releasing hormone receptor 2 |
Database Link | |
Background | CRHR2 is a novel member of Secretin-family-GPCR proteins that functions as a functional receptor for CRF. It is expressed as 3 isoforms; alpha, beta and gamma. These isoforms primarily differ in their N-terminal sequence and tissue distribution. Apart from CRF, other ligands of CRHR2 include UcnI, UcnII and UcnIII. CRHR2 is involved in stress responses, cardiovascular function and gastric motility. Studies on CRHR2 deficient mice suggested a central anxiolytic effect of CRHR2. Northern Blot analysis detects CRHR2 expression in brain, hypothalamus, heart, GI, lung, skeletal muscle and vasculature. |
Synonyms | CRF-RB; CRF2; CRFR2; HM-CRF |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Neuroactive ligand-receptor interaction |
Documents
Product Manuals |
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