Corticotropin Releasing Factor Receptor 2 (CRHR2) Rabbit Polyclonal Antibody

CAT#: TA336366

Rabbit Polyclonal CRHR2/CRF2 Antibody

Product Images

Simple Western: CRHR2/CRF2 Antibody TA336366 - Shows a specific band for Corticotropin Releasing Factor 2 in 0.5 mg/ml of Human Brain lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.

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  Western Blot: CRHR2/CRF2 Antibody TA336366 - Analysis of CRHR2 in human brain lysate in the 1) absence and 2) presence of immunizing peptide using this antibody. Both of the isoforms detected by this antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Immunocytochemistry/ Immunofluorescence, Simple Western: 1:200, Western Blot: 0.5-2 ug/ml
• Reactivities: Human, Mouse, Rat, Bovine, Canine, Chicken
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A portion of amino acids 75-125 of human CRHR2 was used as the immunogen.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: corticotropin releasing hormone receptor 2
• Database Link:
  NP_001874
  Entrez Gene 12922 MouseEntrez Gene 64680 RatEntrez Gene 1395 Human
  UniProt ID Q13324
• Background: CRHR2 is a novel member of Secretin-family-GPCR proteins that functions as a functional receptor for CRF. It is expressed as 3 isoforms; alpha, beta and gamma. These isoforms primarily differ in their N-terminal sequence and tissue distribution. Apart from CRF, other ligands of CRHR2 include UcnI, UcnII and UcnIII. CRHR2 is involved in stress responses, cardiovascular function and gastric motility. Studies on CRHR2 deficient mice suggested a central anxiolytic effect of CRHR2. Northern Blot analysis detects CRHR2 expression in brain, hypothalamus, heart, GI, lung, skeletal muscle and vasculature.
• Synonyms: CRF-RB; CRF2; CRFR2; HM-CRF

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction