C5L2 (C5AR2) Rabbit Polyclonal Antibody

CAT#: TA336368

Rabbit Polyclonal C5L2/GPR77 Antibody

Product Images

Western Blot: GPR77 Antibody TA336368 - Analysis of GPR77 in human testis cell lysate in the 1) absence and 2) presence of immunizing peptide using this antibody at 0.5 ug/ml.

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  Immunohistochemistry-Paraffin: GPR77 Antibody TA336368 - IHC analysis of human liver using TA336368 at 10 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 0.5-2 ug/ml, IF: 1:10-1:500, IHC: , IHC-P: 10 ug/ml
• Reactivities: Human, Primate
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A portion of amino acids 1-50 of human GPR77 was used as the immunogen.
• Formulation: PBS, 0.02% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: complement component 5a receptor 2
• Database Link:
  NP_060955
  Entrez Gene 27202 Human
  UniProt ID Q9P296
• Background: Official Gene Symbol: GPR77 Gen Bank Accession Number: NP_060955 Gene ID: 27202 (human) Gene Map Locus: 19q13.33 (human) C5L2 is 337A.A orphan member that belongs to anaphylatoxin receptor family. It is a seven transmembrane G-protein-coupled receptor consisting of an N-terminal N-glycosylation site, several conserved cysteines and several potential C-terminal phosphorylation sites. It binds to C5a and C5a-des-Arg and serves as a highly regulated scavenger receptor with a negative modulatory influence on C5aR-mediated inflammation. Northern Blot analysis suggests it is co- expressed along with C5aR in different tissues and cells including neutrophils/macrophages, mast cells, dendritic cells, brain, lung, heart, kidney, liver, ovary and testis.
• Synonyms: C5L2; GPF77; GPR77
• Note: Immunocytochemistry/Immunofluorescence: See Bamberg et al (2010) for details.

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane