TACI (TNFRSF13B) Rabbit Polyclonal Antibody

CAT#: TA336380

Rabbit Polyclonal TACI/TNFRSF13B/CVID Antibody

Product Images

Western Blot: TACI/TNFRSF13B/CVID Antibody TA336380 - Analysis of A) human spleen, B) mouse spleen, C) human stomach, D) and mouse stomach lysate using TACI antibody at 2 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Immunohistochemistry, Western Blot: 0.5-2 ug/ml
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: This rabbit polyclonal antibody was developed against a synthetic peptide corresponding to amino acids 116-132 of human TACI. Human and mouse TACI amino acid sequences are 65% conserved in the immunogen.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tumor necrosis factor receptor superfamily member 13B
• Database Link:
  NP_036584
  Entrez Gene 57916 MouseEntrez Gene 23495 Human
  UniProt ID O14836
• Background: Simultaneously four different laboratories identified a a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 (1), THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase (2), BAFF (for B cell activating factor belonging to the TNF family) (3) and BlyS (B lymphocyte stimulator) (4). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The receptor for BlyS/BAFF appears to be expressed predominantly on B cells and activated T cells (5). Recently two orphan receptors TACI (6) and BCMA (,8) have been shown to be receptors for BlyS/BAFF (6-9). TACI is expressed on B cells and signals through CAML, activating the transcription factors NF-AT, NF-kB, and AP-1. TACI is a type III transmembrane protein, as defined by the lack of a cleaved signal sequence and its N-terminal extracellular exposure. The cDNA codes for 293 amino acids with predicted molecular weight of approx. 32 kDa.
• Synonyms: CD267; CVID; CVID2; IGAD2; RYZN; TACI; TNFRSF14B

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Primary immunodeficiency