IL17E (IL25) Mouse Monoclonal Antibody [Clone ID: 68C1039.2]

CAT#: TA336397

Mouse Monoclonal IL-17E/IL-25 Antibody (68C1039.2)

Product Images

Western Blot: IL-17E/IL-25 Antibody (68C1039.2) TA336397 - Analysis of IL-17E using IL-17E monoclonal antibody. Mouse testis lysate probed with IL-17E antibody at 2 ug/mL.

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  Immunohistochemistry-Paraffin: IL-17E/IL-25 Antibody (68C1039.2) TA336397 - Adrenal cortex, Human

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  Immunohistochemistry-Paraffin: IL-17E/IL-25 Antibody (68C1039.2) TA336397 - Tissue section of mouse liver using IL17E/IL25 antibody clone 68C1039.2 at 1:150. The antibody generated a diffused cytoplasmic staining in the hepatocytes with a very strong signal in the sinusoidal endothelial cells.

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  Immunohistochemistry-Paraffin: IL-17E/IL-25 Antibody (68C1039.2) TA336397 - Tissue section of mouse kidney using IL17E/IL25 antibody clone 68C1039.2 at 1:150. The antibody generated a diffused cytoplasmic staining in the tubular and ductal epithelia cells, and a strong positivity in the inter-tubular/ductal blood vessels.

Specifications

Product Data

• Clone Name: 68C1039.2
• Applications: IHC, WB
• Recommended Dilution: Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Western Blot: 1:100 - 1:250, Immunohistochemistry: 1:100 - 1:500
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Amino acids 115-132 of human IL-17E (isoform CRA_a) were used as immunogen for this antibody.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 20 kDa
• Gene Name: interleukin 25
• Database Link:
  NP_758525
  Entrez Gene 140806 MouseEntrez Gene 64806 Human
  UniProt ID Q9H293
• Background: A number of cytokines belonging to the interleukin (IL)-17 family have been identified, termed IL-17A-F. IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis, multiple sclerosis, and promotion of tumor growth. IL-17E, C, and B are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that an additional IL-17R related receptor may exist. Receptors for IL-17B and IL-17E have been independently isolated by Shi, et al and Lee, et al. and have been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E, also called IL-25, induces activation of NF-kB pathway and like IL-17 also induces production of IL-8.
• Synonyms: IL17E
• Note: IHC-Paraffin reported in literature (see Terrier B, et al).

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction