TLR2 Rabbit Polyclonal Antibody

CAT#: TA336413

Rabbit Polyclonal TLR2 Antibody

Product Images

Western Blot: TLR2 Antibody TA336413 - Analysis of TLR2 in (A) 15 ugs of Raw cell lysate (B) Mouse TLR2 transfected cell lysate and (C) Ramos cell lysate. 1 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Immunohistochemistry, Western Blot: 0.5-2 ug/ml, Immunohistochemistry-Paraffin
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: This antibody was developed against an extracellular domain of mouse TLR2 (amino acids 564-580 and 751-770).
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: toll like receptor 2
• Database Link:
  NP_003255
  Entrez Gene 24088 MouseEntrez Gene 7097 Human
  UniProt ID O60603
• Background: The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). TLR2 is differentially expressed in human cells. TLR2 is expressed in tonsils, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes expressed the highest level of TLR2 followed by CD15+ granulocytes, and CD19+ B-cells, CD3+ T-cells, and CD56+ NK cells did not express TLR2. The expression of TLR2 in different cell types is regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up-regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes (4).
• Synonyms: CD282; TIL4

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Toll-like receptor signaling pathway