FOXP3 Mouse Monoclonal Antibody [Clone ID: 3G3]
Frequently bought together (2)
Transient overexpression lysate of forkhead box P3 (FOXP3), transcript variant 1
USD 605.00
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Specifications
Product Data | |
Clone Name | 3G3 |
Applications | FC, WB |
Recommended Dilution | Western Blot: 2 - 5 ug/mL, Flow Cytometry: 100 ng/ 10^6 cells in 50 uL |
Reactivities | Human, Mouse |
Host | Mouse |
Isotype | IgG1, kappa |
Clonality | Monoclonal |
Immunogen | Full-length His-tagged murine FOXP3 was used as the immunogen. The precise epitope is not known, but it has been mapped to the N-terminal portion of the protein (NP_001107849). |
Formulation | PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at -20C. Avoid freeze-thaw cycles. |
Concentration | lot specific |
Purification | Protein G purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 47 kDa |
Gene Name | forkhead box P3 |
Database Link | |
Background | One of the many immunotolerance mechanisms that the immune system has developed to distinguish between self and non-self antigens is regulatory T cells or Tregs. Several elegant experiments using transgenic mice and retrovirus-mediated over expression studies, have led to the identification of FoxP3, a transcription factor, as a specific molecular marker essential for the development and function of Tregs. The primary evidence regarding the involvement of FoxP3 in the development of Tregs was provided in patients suffering from IPEX, a rare and fatal human autoimmune disease. The emergence of Tregs and the role of FoxP3 as a critical player in the negative control of various normal and pathological immune responses holds great promise for the development of novel therapies for autoimmune diseases. |
Synonyms | AIID; DIETER; IPEX; JM2; PIDX; XPID |
Reference Data | |
Protein Families | Transcription Factors |
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