ATF2 Mouse Monoclonal Antibody [Clone ID: 103C411.2]

CAT#: TA336422

Mouse Monoclonal ATF2 [p Thr71] Antibody (103C411.2)

Product Images

Western Blot: ATF2 [p Thr71] Antibody (103C411.2) TA336422 - Detection of ATF2 phosphorylation in HeLa cell lysate with phospho ATF2 antibody. Lane A. Untreated cell lysate; Lane B. HeLa cells treated with TNF for 1 hr.

Specifications

Product Data

• Clone Name: 103C411.2
• Applications: FC
• Recommended Dilution: Flow Cytometry: 1:10-1:1000, Western Blot: 2 ug/ml
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: This antibody was generated by immunizing mice with a synthetic peptide containing phosphorylated threonine at position 71 of human ATF-2.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: activating transcription factor 2
• Database Link:
  NP_001243019
  Entrez Gene 1386 Human
  UniProt ID P15336
• Background: ATF-2 is a member of the group of bZip transcription factors. Heterodimer formation between members of the bZip group is common and is believed to add diversity to the cis-acting elements at which binding of the dimers is directed. Specifically, ATF-2 may dimerize with c-Jun, as occurs in response to E1a, and in so doing shift the binding preference of c-Jun toward ATF/CRE sites. Deletion analysis has indicated that the N-terminal region of ATF-2 containing threonine at residues 69 and 71 are essential for this purpose. These threonine residues are phosphorylated by JNK/SAPK for transcriptional activation.
• Synonyms: CRE-BP1; CREB-2; CREB2; HB16; TREB7

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: MAPK signaling pathway