SETD7 Rabbit Polyclonal Antibody

CAT#: TA336441

Rabbit Polyclonal SETD7/9 Antibody

Product Images

Immunohistochemistry-Paraffin: SETD7/9 Antibody TA336441 - Analysis of human small instestine using SETD7 antibody at 1:100.

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  Western Blot: SETD7/9 Antibody TA336441 - Analysis of SETD7 in A) MCF7 and B) HeLa lysate using SETD7 antibody at 1:500.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Chromatin Immunoprecipitation (ChIP): 1:10-1:500, Western Blot: 1:500-1:1000, Immunohistochemistry-Paraffin: 1:100, Immunohistochemistry
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Two synthethic peptides corresponding to amino acids 131-145 (GEVNEDGEMTGEKIA) and 336-352 (GYDHSPPGKSGPEAPEW) of human SETD7 were used as immunogen for this antibody.
• Formulation: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Whole antisera
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: SET domain containing lysine methyltransferase 7
• Database Link:
  NP_085151
  Entrez Gene 73251 MouseEntrez Gene 80854 Human
  UniProt ID Q8WTS6
• Background: Diverse signal transduction pathways impinging on the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly(ADP-ribosylation), ubiquitination and methylation. These modifications play critical roles in regulating chromatin structure and gene expression. Histone methyltransferases (HMTases) selectively methylate evolutionarily conserved arginine or lysine residues, primarily in the N-terminal tails of histones H3 and H4. Set7/9 is a histone specific HMTase that methylates histone H3 lysine 4. Set7/9 transfers methyl groups to lysine 4 of histone H3 in complex with S-adenosyl-L-methionine. Human Set7/9 is a 336 amino acid protein.
• Synonyms: 9; KMT7; SET7; SET9

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Lysine degradation