TLR7 Rabbit Polyclonal Antibody

CAT#: TA336447

Rabbit Polyclonal TLR7 Antibody

Product Images

Immunohistochemistry-Paraffin: TLR7 Antibody TA336447 - Analysis of TLR7 in formalin-fixed, paraffin-embedded human lung tissue using an isotype control (top) and this antibody (bottom) at 1:100.

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  Western Blot: TLR7 Antibody TA336447 - Analysis of TLR7 in Ramos cell lysate using TA336447 at 1:500.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1:500-1:1000, Immunohistochemistry-Paraffin: 1:100, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: This antibody was developed against KLH-conjugated synthetic peptide corresponding to amino acids 465-483 of human TLR7.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: toll like receptor 7
• Database Link:
  NP_057646
  Entrez Gene 170743 MouseEntrez Gene 51284 Human
  UniProt ID Q9NYK1
• Background: The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1) and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described (3). Stimulation of the NFkB signaling pathway by TLR7 suggests that it plays a role in immune response.
• Synonyms: TLR7-like

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Toll-like receptor signaling pathway