TRF2 (TERF2) Goat Polyclonal Antibody

CAT#: TA336448

Goat Polyclonal TRF-2 Antibody


USD 424.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications IHC, IP
Recommended Dilution Immunoprecipitation: 2 ug/ 10^6 cells, Western Blot: 2 ug/ml, Immunohistochemistry-Paraffin: 15 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunohistochemistry: 1:10-1:500, Flow Cytometry, Knockdown Validated, Chromatin Immunoprecipitation (ChIP): 1:20-1:1000
Reactivities Human, Mouse
Host Goat
Clonality Polyclonal
Immunogen Baculovirus expressed His-tagged whole length TRF2 protein was used for immunizing goat (NP_005643).
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name telomeric repeat binding factor 2
Background TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
Synonyms TRBF2; TRF2
Reference Data
Protein Families Transcription Factors

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.