IRAK (IRAK1) Rabbit Polyclonal Antibody

CAT#: TA336450

Rabbit Polyclonal IRAK1 Antibody


USD 402.00

5 Days*

Size
    • 100 ug

Product Images

Frequently bought together (2)
Transient overexpression lysate of interleukin-1 receptor-associated kinase 1 (IRAK1), transcript variant 1
    • 100 ug

USD 605.00


beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

USD 159.00

Other products for "IRAK"

Specifications

Product Data
Applications WB
Recommended Dilution Immunoprecipitation: 2-4 ug per sample, Western Blot: 1 - 5 ug/ml
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Rabbit anti-IRAK polyclonal antibody was raised against a peptide corresponding to amino acids 700 to 712 of human IRAK.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name interleukin 1 receptor associated kinase 1
Background Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently (3,4). IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response (2). IRAK mediates a signaling cascade leading to NF-kB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF) (1,4).
Synonyms IRAK; pelle
Reference Data
Protein Families Druggable Genome, Protein Kinase, Transcription Factors
Protein Pathways Apoptosis, Neurotrophin signaling pathway, Toll-like receptor signaling pathway

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.