IRAK (IRAK1) Rabbit Polyclonal Antibody

CAT#: TA336450

Rabbit Polyclonal IRAK1 Antibody

Product Images

Western Blot: IRAK1 Antibody TA336450 - IRAK Antibody TA336450 - Analysis of IRAK-1 in 1) human HeLa and 2) mouse NIH3T3 lysate using IRAK-1 antibody at 1 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Immunoprecipitation: 2-4 ug per sample, Western Blot: 1 - 5 ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Rabbit anti-IRAK polyclonal antibody was raised against a peptide corresponding to amino acids 700 to 712 of human IRAK.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 1 receptor associated kinase 1
• Database Link:
  NP_001560
  Entrez Gene 16179 MouseEntrez Gene 363520 RatEntrez Gene 3654 Human
  UniProt ID P51617
• Background: Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently (3,4). IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response (2). IRAK mediates a signaling cascade leading to NF-kB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF) (1,4).
• Synonyms: IRAK; pelle

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transcription Factors
• Protein Pathways: Apoptosis, Neurotrophin signaling pathway, Toll-like receptor signaling pathway